Protect each breath she takes, so you can catch yours


INFORCE 3® makes respiratory disease protection second nature, not second guessing

Helps protect against three major respiratory viral pathogens — bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza 3 (PI3) virus.

Intranasal administration triggers a quick, local response where pathogens first attack.

Provides up to six months of IBR immunity and flexibility to revaccinate calves or cows when protection is most needed.

Protect your peace of mind

Dairy calves, heifers and cows are susceptible to bovine respiratory disease (BRD), or pneumonia, caused by a variety of viral pathogens, like BRSV. These diseases have immediate effects, and also can rob them of health and productivity throughout their life. Help stop these challenges before they start by arming your herd with the respiratory protection of INFORCE 3® respiratory vaccine.


May impede optimal productivity.

  • The risk for death in calves and heifers was numerically higher in BRSV‑infected herds.1
  • BRSV continues to circulate in adult cattle, many times undetected, resulting in the transfer of BRSV‑specific maternal antibodies in unvaccinated herds.2
  • One study found a significant reduction in milk yield for herds with BRSV-related outbreaks compared with infection‑free herds.1

Boost immunity at the right time

Bolstering immunity against respiratory disease during key stages can help keep your herd healthy and productive. Using INFORCE 3® can result in healthier calves, heifers and cows, resulting in fewer culls, fewer losses from pneumonia caused by BRSV, IBR and PI3 and, ultimately, more milk. Higher milk production means more profit — about $192 per cow per year, a study by Zoetis and Compeer Financial found.*,4


Give her a healthy start

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An intranasal vaccine delivered three days after birth can help stimulate immunity where pathogens attack first — the nose. As a calf’s immune system develops, vaccination will help trigger a quick immune response and help prime the immune system for a memory response to subsequent disease challenges.

INFORCE 3®, the leading cattle respiratory vaccine on the market since 2015,5 helps boost respiratory disease prevention efforts for calves against BRSV, IBR and PI3.

Tips for a cleaner calving area


Boost her immunity at weaning

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Weaning and getting moved into group housing can be stressful for calves. And, it can leave them susceptible to respiratory disease. INFORCE 3® can be administered at the time of weaning to help boost the immunity of INFORCE 3 given at birth.

Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age to avoid possible maternal antibody interference with immunization.

Two ways to minimize weaning stress and BRD


Protection in the fresh pen

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Heifers and cows are highly stressed before and after birth, which leads to a greatly depressed immune system and increased susceptibility to harmful respiratory pathogens, like BRSV.

Respiratory disease prevention is vital to maintaining the health and wellness — and positive production — of prefresh heifers and cows.

Respiratory protection isn’t just for calves

Breathe easier at every stage of her life

Vaccination with INFORCE 3® provides valuable protection and comes with support from experts that only Zoetis brings to your operation.

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Explore more ways to help prevent respiratory disease

Our portfolio of respiratory disease vaccinations helps maintain health and productivity for your herd and operation.



ONE SHOT® BVD and INFORCE 3® can help better protect young calves and build immunity prior to commingling.



BOVI-SHIELD GOLD® 5 helps protect pregnant cows against IBR, bovine viral diarrhea (BVD) Types 1 and 2, PI3, and BRSV.



BOVI‑SHIELD GOLD ONE SHOT® delivers a combination respiratory vaccination to help protect calves during the stress of weaning.